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FGF-based drug discovery: advances and challenges
Human fibroblast growth factors (FGFs) act in a paracrine or endocrine fashion to regulate a myriad of vital processes in development, metabolism, and tissue homeostasis 1.
The FGF family: biology, pathophysiology and therapy
FGFs are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis: the first five subfamilies fall into this …
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Fibroblast Growth Factors (FGFs) and their cognate receptors, FGFRs, play pivotal roles in a plethora of biological processes, including cell proliferation, differentiation, tissue repair, and …
Pathology and Therapeutic Significance of Fibroblast Growth …
Abstract The fibroblast growth factor (FGF) family includes 22 proteins in humans. Based on their mode of action, there are three families of FGFs: paracrine FGFs (FGF 1–10, 16, 17, 18, 20, …
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Fibroblast Growth Factor
Fibroblast growth factors (FGFs) comprise a family of structurally related polypeptide mitogens, which in vertebrates comprise 22 members [1]. FGFs bind heparin, heparan sulfate …
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Fibroblast growth factors: properties, biosynthesis, biological ...
Fibroblast Growth Factors (FGFs) function as signaling molecules within various signaling pathways, regulating the proliferation, migration, and differentiation of soft connective tissues, …
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Fibroblast Growth Factor Family (FGF)
Fibroblast Growth Factors (FGFs) are potent regulators of cell proliferation and differentiation. They are critically important in normal development, tissue maintenance, wound repair, and …
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Fibroblast Growth Factor (FGF) Family
FGF, also known as fibroblast growth factor, represents a family of approximately two dozen heparin-binding proteins that play pivotal roles in numerous cellular processes related to …
Fibroblast growth factor
FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous …
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